Date Published: April 1, 2018
Publisher: JKL International LLC
Author(s): Chuanjie Wu, Di Wu, Jian Chen, Chuanhui Li, Xunming Ji.
Acute ischemic stroke continues to be a very severe disorder that has significant impact on human health. Its treatment options are limited and alteplase remains the only American Food and Drug Administration-approved drug for patients with acute ischemic stroke. Furthermore, intravenous thrombolysis remains substantially underutilized, because it has rigorous indications and contraindications. Most patients simply do not meet these criteria and cannot receive thrombolytic treatment. Guidelines in many countries currently include a history of stroke within months as one of the exclusion criteria for intravenous thrombolysis. Although this is based on previous data, it lacks strong evidentiary support. Several recent studies suggested that intravenous thrombolysis may be beneficial for this patient population. We reviewed relevant publications of intravenous thrombolysis or repeated intravenous thrombolysis in patients with a history of stroke in the past 3 months. We found that intravenous thrombolysis in these patients is not as hazardous as previously believed. Among patients with relatively small infarctions and a good prognosis, intravenous thrombolysis may be a good treatment option. We hope that more research will be carried out on this topic to reexamine the criteria for intravenous thrombolysis to allow more patients to benefit from treatment.
Studies of intravenous thrombolysis or repeated intravenous thrombolysis in patients with a history of stroke in the past 3 months were identified from PubMed (January 1995 – September 2016). We identified relevant studies using the relevant text words and medical subject headings about stroke, cerebrovascular disease, cerebral vascular occlusion, repeated intravenous thrombolysis, intravenous thrombolysis, recurrent, alteplase, urokinase. In addition, we examined the reference lists and related links of retrieved articles in PubMed to detect studies potentially eligible for inclusion.