suprachiasmatic nucleus | definition

area of the hypothalamus in which the body’s biological clock is located


Spielman, R. M., Jenkins, W. J., & Lovett, M. D. (2020). Psychology 2e. Houston, Texas: OpenStax. Access for free at


Research Article: Antibodies for Assessing Circadian Clock Proteins in the Rodent Suprachiasmatic Nucleus

Date Published: April 27, 2012 Publisher: Public Library of Science Author(s): Joseph LeSauter, Christopher M. Lambert, Margaret R. Robotham, Zina Model, Rae Silver, David R. Weaver, Shin Yamazaki. Abstract Research on the mechanisms underlying circadian rhythmicity and the response of brain and body clocks to environmental and physiological challenges requires assessing levels of circadian clock … Continue reading

Research Article: The Role of the Suprachiasmatic Nucleus in Cardiac Autonomic Control during Sleep

Date Published: March 24, 2016 Publisher: Public Library of Science Author(s): S. D. Joustra, R. H. Reijntjes, A. M. Pereira, G. J. Lammers, N. R. Biermasz, R. D. Thijs, Raffaele Ferri. Abstract: The suprachiasmatic nucleus (SCN) may play an important role in central autonomic control, since its projections connect to (para)sympathetic relay stations in … Continue reading

Research Article: Intrinsic Regulation of Spatiotemporal Organization within the Suprachiasmatic Nucleus

Date Published: January 7, 2011 Publisher: Public Library of Science Author(s): Jennifer A. Evans, Tanya L. Leise, Oscar Castanon-Cervantes, Alec J. Davidson, Shin Yamazaki. Abstract: The mammalian pacemaker in the suprachiasmatic nucleus (SCN) contains a population of neural oscillators capable of sustaining cell-autonomous rhythms in gene expression and electrical firing. A critical question for understanding … Continue reading

Research Article: Synchronization-Induced Rhythmicity of Circadian Oscillators in the Suprachiasmatic Nucleus

Date Published: April 13, 2007 Publisher: Public Library of Science Author(s): Samuel Bernard, Didier Gonze, Branka Čajavec, Hanspeter Herzel, Achim Kramer, Karl J Friston Abstract: The suprachiasmatic nuclei (SCN) host a robust, self-sustained circadian pacemaker that coordinates physiological rhythms with the daily changes in the environment. Neuronal clocks within the SCN form a heterogeneous network … Continue reading

Research Article: Phase Differences in Expression of Circadian Clock Genes in the Central Nucleus of the Amygdala, Dentate Gyrus, and Suprachiasmatic Nucleus in the Rat

Date Published: July 28, 2014 Publisher: Public Library of Science Author(s): Valerie L. Harbour, Yuval Weigl, Barry Robinson, Shimon Amir, Paul A. Bartell. Abstract: We performed a high temporal resolution analysis of the transcript level of two core clock genes, Period2 (Per2) and Bmal1, and a clock output gene, Dbp, in the suprachiasmatic nucleus … Continue reading

Research Article: Photic Desynchronization of Two Subgroups of Circadian Oscillators in a Network Model of the Suprachiasmatic Nucleus with Dispersed Coupling Strengths

Date Published: May 16, 2012 Publisher: Public Library of Science Author(s): Changgui Gu, Zonghua Liu, William J. Schwartz, Premananda Indic, Shin Yamazaki. Abstract: The suprachiasmatic nucleus (SCN) is the master circadian clock in mammals and is composed of thousands of neuronal oscillators expressing different intrinsic periods. These oscillators form a coupled network with a free-running … Continue reading

Research Article: Intracellular Calcium Spikes in Rat Suprachiasmatic Nucleus Neurons Induced by BAPTA-Based Calcium Dyes

Date Published: March 10, 2010 Publisher: Public Library of Science Author(s): Jin Hee Hong, Cheol Hong Min, Byeongha Jeong, Tomoyoshi Kojiya, Eri Morioka, Takeharu Nagai, Masayuki Ikeda, Kyoung J. Lee, Shin Yamazaki. Abstract: Circadian rhythms in spontaneous action potential (AP) firing frequencies and in cytosolic free calcium concentrations have been reported for mammalian circadian pacemaker … Continue reading

Research Article: The day/night difference in the circadian clock’s response to acute lipopolysaccharide and the rhythmic Stat3 expression in the rat suprachiasmatic nucleus

Date Published: September 28, 2018 Publisher: Public Library of Science Author(s): Simona Moravcová, Dominika Pačesová, Barbora Melkes, Hana Kyclerová, Veronika Spišská, Jiří Novotný, Zdenka Bendová, Henrik Oster. Abstract The circadian clock in the suprachiasmatic nucleus (SCN) regulates daily rhythms in physiology and behaviour and is an important part of the mammalian homeostatic system. Previously, … Continue reading