trypsin | definition

pancreatic enzyme that activates chymotrypsin and digests protein


Betts, J. G., Young, K. A., Wise, J. A., Johnson, E., Poe, B., Kruse, D. H., … DeSaix, P. (n.d.). Anatomy and Physiology. Houston, Texas: OpenStax. Access for free at:

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Research Article: Trypsin Potentiates Human Fibrocyte Differentiation

Date Published: August 7, 2013 Publisher: Public Library of Science Author(s): Michael J. V. White, Melissa Glenn, Richard H. Gomer, Mauricio Rojas. Abstract Trypsin-containing topical treatments can be used to speed wound healing, although the mechanism of action is unknown. To help form granulation tissue and heal wounds, monocytes leave the circulation, enter the … Continue reading

Research Article: Trypsin-Catalyzed Deltamethrin Degradation

Date Published: March 3, 2014 Publisher: Public Library of Science Author(s): Chunrong Xiong, Fujin Fang, Lin Chen, Qinggui Yang, Ji He, Dan Zhou, Bo Shen, Lei Ma, Yan Sun, Donghui Zhang, Changliang Zhu, David L. McCormick. Abstract To explore if trypsin could catalyze the degradation of non-protein molecule deltamethrin, we compared in vitro hydrolytic … Continue reading

Research Article: Enhanced trypsin on a budget: Stabilization, purification and high-temperature application of inexpensive commercial trypsin for proteomics applications

Date Published: June 27, 2019 Publisher: Public Library of Science Author(s): Søren Heissel, Sigurd J. Frederiksen, Jakob Bunkenborg, Peter Højrup, Andy T. Y. Lau. Abstract Trypsin is by far the most commonly used protease in proteomics. Even though the amount of protease used in each experiment is very small, digestion of large amounts of … Continue reading

Research Article: Crystal Structures of a Plant Trypsin Inhibitor from Enterolobium contortisiliquum (EcTI) and of Its Complex with Bovine Trypsin

Date Published: April 23, 2013 Publisher: Public Library of Science Author(s): Dongwen Zhou, Yara A. Lobo, Isabel F. C. Batista, Rafael Marques-Porto, Alla Gustchina, Maria L. V. Oliva, Alexander Wlodawer, Bostjan Kobe. Abstract A serine protease inhibitor from Enterolobium contortisiliquum (EcTI) belongs to the Kunitz family of plant inhibitors, common in plant seeds. It was … Continue reading

Research Article: Autocrine Extra-Pancreatic Trypsin 3 Secretion Promotes Cell Proliferation and Survival in Esophageal Adenocarcinoma

Date Published: October 11, 2013 Publisher: Public Library of Science Author(s): Song Han, Constance W. Lee, Jose G. Trevino, Steven J. Hughes, George A. Sarosi, Arun Rishi. Abstract Trypsin or Tumor associated trypsin (TAT) activation of Protease-activated receptor 2 (PAR-2) promotes tumor cell proliferation in gastrointestinal cancers. The role of the trypsin/PAR-2 network in … Continue reading

Research Article: Binding of Tetracycline and Chlortetracycline to the Enzyme Trypsin: Spectroscopic and Molecular Modeling Investigations

Date Published: December 19, 2011 Publisher: Public Library of Science Author(s): Zhenxing Chi, Rutao Liu, Hongxu Yang, Hengmei Shen, Jing Wang, Hendrik W. van Veen. Abstract Tetracycline (TC) and chlortetracycline (CTC) are common members of the widely used veterinary drug tetracyclines, the residue of which in the environment can enter human body, being potentially harmful. … Continue reading

Research Article: Tyrosine Sulfation of Human Trypsin Steers S2’ Subsite Selectivity towards Basic Amino Acids

Date Published: July 10, 2014 Publisher: Public Library of Science Author(s): András Szabó, Moh’d A. Salameh, Maren Ludwig, Evette S. Radisky, Miklós Sahin-Tóth, Andrea Motta. Abstract Human cationic and anionic trypsins are sulfated on Tyr154, a residue which helps to shape the prime side substrate-binding subsites. Here, we used phage display technology to assess … Continue reading

Research Article: Trypsin-Like Serine Proteases in Lutzomyia longipalpis – Expression, Activity and Possible Modulation by Leishmania infantum chagasi

Date Published: May 18, 2010 Publisher: Public Library of Science Author(s): Erich Loza Telleria, Adriana Pereira Oliveira de Araújo, Nágila Francinete Secundino, Claudia Masini d’Avila-Levy, Yara Maria Traub-Csekö, Ben L. Kelly. Abstract: Midgut enzymatic activity is one of the obstacles that Leishmania must surpass to succeed in establishing infection. Trypsins are abundant digestive enzymes in … Continue reading

Research Article: Investigate the Binding of Catechins to Trypsin Using Docking and Molecular Dynamics Simulation

Date Published: May 4, 2015 Publisher: Public Library of Science Author(s): Fengchao Cui, Kecheng Yang, Yunqi Li, Eugene A. Permyakov. Abstract To explore the inhibitory mechanism of catechins for digestive enzymes, we investigated the binding mode of catechins to a typical digestive enzyme-trypsin and analyzed the structure-activity relationship of catechins, using an integration of … Continue reading

Research Article: Cold Adaptation, Ca2+ Dependency and Autolytic Stability Are Related Features in a Highly Active Cold-Adapted Trypsin Resistant to Autoproteolysis Engineered for Biotechnological Applications

Date Published: August 12, 2013 Publisher: Public Library of Science Author(s): Alvaro Olivera-Nappa, Fernando Reyes, Barbara A. Andrews, Juan A. Asenjo, Annalisa Pastore. Abstract Pig trypsin is routinely used as a biotechnological tool, due to its high specificity and ability to be stored as an inactive stable zymogen. However, it is not an optimum … Continue reading